Mid-term, syllabus of Biochem-508: Nucleic acids and their importance. Structures of nitrogenous bases, pentoses and their properties. Structures and functions of nucleotides. Phosphodiester bond and polynucleotides. Double helical structure of DNA and its characteristics. Different three-dimensional forms of DNA; A, B and Z forms.  Unusual structures of DNA. Denaturation and hybridization of nucleic acids. Non-enzymatic transformations of DNA.  

…. PLUS…. First 150 MCQs from chapters 9 of the book ” MCQs in Biochemistry”. MCQs from the taught concepts and book chapters will also appear in the exam.

Final exam, syllabus of Biochem-508: Nucleic acid fractionation and sequencing. Chemical synthesis of DNA, Intronic and exonic regions, Molecular structures and functions of mRNA, rRNA, tRNA and small nuclear RNA. Nucleic acids interacting agents, chemical reactions of Nucleic Acids, Ribozymes and their characteristics. Pathways of information flow. Biosynthesis and biodegradation of purine and pyrimidine nucleotides, regulation of nucleotide metabolism. Inborn error of nucleic acid metabolism.. 

…. PLUS…. First 150 MCQs from chapters  9 of the book ” MCQs in Biochemistry”. MCQs from the taught concepts and book chapters will also appear in exam. Mid term syllabus will be included in final exam.

Assignments and presentations: 

  1. The weightage of the assignment and presentation will be decided later. 
  2. Start preparing your presentations and assignments.
  3. The presentations will also be started right after the mid-term exam.
  4. PPT file should not contain any designing/colours other than figures and diagrams.
  5. Slides should be in 16X9 ratio.
  6. Fonts of all header should be same and of all other text should be same. 
  7. For detailed guidelines about the presentation of research article, visit: https://www.lifesciencesorg.combiochem-720/
  8. Download the template ppt file to make your presentation. The link is here (copy this link and paste in a new tab).
  9. Strictly follow the ppt format and it is better if you write and paste your material in the same ppt file.

K. General Question to be asked during presentation

  1. 1) Pathway or importance of gene/technology/discovery
  2. 2) Rationale
  3. 3) Conclusion of the full article
  4. 4) Conclusion of every figure
  5. 5) New findings presented in the article
  6. 6) Applications of the findings
  7. 7) Future prospective
  8. 8) Applications of the work
  9. 9) Principle of every technique used in the research article

Moreover, provide me a printed summary of your article containing the above headings given under ‘K’.

L. During Presentations, for EVERY FIGURE and graph, we may ask:

1. The Principle of the experiment.
2. The Reason for doing the experiment.
3. The Physiological importance of the figure.
4. The Conclusions of the figure
5. Prepare well objectively and subjectively

NO EXCUSE WILL BE ACCEPTED

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Link to download the book ( MCQs in Biochemistry) is given below:

https://b-ok.cc/dl/1055171/2292c5


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Microsoft Teams meeting
Join on your computer, mobile app or room device

Click here to join the meeting

Meeting ID: 336 479 908 561
Passcode: aH9EDN

_______________________________________________________________

Microsoft teams will be used whenever online classes will be held. You must make your teams name as follows. 

2017-ag-9382 Haidar Iftikhar

2017-ag-10077 Ahmad Faraz

BIOCHEM-508                     BIOCHEMISTRY OF NUELEIC ACIDS                                   2(2-0)

 Course Contents

 Theory

Nucleic acids and their importance. Structures of nitrogenous bases, pentoses and their properties. Structures and functions of nucleotides. Phosphodiester bond and polynucleotides. Double helical structure of DNA and its characteristics. Different three-dimensional forms of DNA; A, B and Z forms.  Unusual structures of DNA. Denaturation and hybridization of nucleic acids. Non-enzymatic transformations of DNA. Nucleic acid fractionation and sequencing. Chemical synthesis of DNA, Intronic and exonic regions, Molecular structures and functions of mRNA, rRNA, tRNA and small nuclear RNA. Nucleic acids interacting agents, chemical reactions of Nucleic Acids, Ribozymes and their characteristics. Pathways of information flow. Biosynthesis and biodegradation of purine and pyrimidine nucleotides, regulation of nucleotide metabolism. Inborn error of nucleic acid metabolism.

 Suggested Readings

  1. Molecular Cell Biology -Lodish 8e (major book for this course)
  2. Molecular Biology-Weaver-5e (major book for this course)
  3. Nelson, D.L and M.M. Cox. 2017. Lehninger Principles of Biochemistry. 7th ed. Worth Publishers, New York, NY, USA. 
  4.  Ferrier, D. R. 2017. Biochemistry: Lippincott’s Illustrated Reviews. 7th ed.  Lippincott Williams and Wilkins. U.S.A.
  5. Brown, T., 2016. Gene Cloning and DNA Analysis. 7th Edition. Blackwell Scientific Publications, Melbourne. ISBN-10 # 1119072565.
  6.  Sambrook, J. F., Russell, D. W. and Irwin, N. 2000. Molecular cloning: A laboratory manual, 3rd ed. Cold Spring Harbor Laboratory press, Cold Spring Harbor, New York, NY, USA. 
  7. Voet, D., Voet, J.G and C.W. Pratt. 2013. Fundamentals of Biochemistry, Life at the Molecular Level. 4th ed. John Wiley & Sons. Inc. New York, NY, USA.
  8. Weaver, R. F. 2012. Molecular Biology. 5th ed. McGraw Hill Higher Education.
Biochem-508, BS  Zool-6 M-Spring 2024, Dr. Muhammad Ali (Assignment of making PPT according to template, link is here)
Sr.Ag No.Student’s NameAssignment
12021-ag-9138AFAF RAMZANEmodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model
22021-ag-9139AHSAN IQBAL
32021-ag-9142AMINA MUSTAFA
42021-ag-9145AQSA NOREEN
52021-ag-9149FARHA AZIN KHALID
62021-ag-9150FIZZA MAQSOO GILLPRMT6 Regulates RAS/RAF Binding and MEK/ERKMediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation
72021-ag-9152GULSHAN MUKHTAR
82021-ag-9153HADIQA ANWAR
92021-ag-9154HAFIIZ MAHAD IQBAL
102021-ag-9155HAFIZA RUBAB ALI
112021-ag-9156HAFIZA SYEDA MAHIN FATIMAImpaired LXRa Phosphorylation Attenuates Progression of Fatty Liver Disease
122021-ag-9157HIRA SATTAR
132021-ag-9158IQRA MUKHTAR
142021-ag-9159IQRA SHEHZADI
152021-ag-9160MAHNOOR SAEED
162021-ag-9161MALAIKA SHAHBAZAldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis
172021-ag-9162MALAIKA TANVEER
182021-ag-9165MINAHIL SAEED
192021-ag-9166MISHAAL ALI
202021-ag-9167MOMINA NADEEM
212021-ag-9168MUHAMMAD FAISALTreatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
222021-ag-9169MUHAMMAD TALHA SHAHID
232021-ag-9170MUHAMMAD TARIQ DOGAR
242021-ag-9171MUHAMMAD USMAN SARWAR
252021-ag-9172MUNEEZA QAMAR
262021-ag-9173NADIA AHSANIn vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
272021-ag-9174NIMRA AFZAL
282021-ag-9176QURRAT UL AIN
292021-ag-9177RABIA HANEEF
302021-ag-9178SAIMA ALTAF
312021-ag-9180SARA FATIMASelective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery
322021-ag-9181SEERAT BABAR
332021-ag-9182SEHAR NASIR
342021-ag-9184SHEEZA MUMTAZ
352021-ag-9185SHUMAYL TAJAMMUL
362021-ag-9186SIDRA HAMEEDPreventing Allograft Rejection by Targeting Immune Metabolism
372021-ag-9188SUFYAN AHMAD
382021-ag-9190UMAR HASEEB
392021-ag-9191WARDA SHAFIQUE
402021-ag-9192ZAHEER ABBAS
412021-ag-9193ZAHWA NOORAlteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-a-Dependent Intensification of Oxidative Stress and Tumor Cell Death
422021-ag-9195ZUNAIRA KANWAL
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46  Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer
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link is here

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